Association of Clinical Relapses With Disease Outcomes in Multiple Sclerosis Patients Older Than 50 Years

Steffen Pfeuffer, Stephanie Wolff, Derya Aslan, et al. Neurology. Originally published July 23, 2024 issue

“A relapse—suggesting underlying active disease—in PwMS older than 50 years was associated with continued disease activity and increased risk of PIRA. Presence of CVRF and absence of DMT at baseline appeared as risk factors of disadvantageous disease courses. An escalation of DMT switch was associated with stable over active but not progressive disease.”